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KMID : 0382319910110020099
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Environmental Mutagens and Carcinogens
1991 Volume.11 No. 2 p.99 ~ p.106
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Intracellular Transport of Benzo(a)pyrene by Chemically Modified Low Density Lipoproteins into Hep 2 Cells
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신인철
윤유식/홍석진/강계원/정안식/조철오
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Abstract
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Facilitated transport of lipophilic benzo(a)pyrene into human fibroblast cells by low density lipoproteins (LDL) was examined. Amounts of [3H]-labeled B(a)P taken up by the Hep 2 fibroblast was increased 3 folds by the addition of LDL (100ng of protein/105 cells) in the media. However, we have found that the facilitated B(a)P transport into cells were diminished by the addition of LDL of which the apoproteins were modified by copper(II) ion-catalyzed oxidation in 10nM copper sulfate.
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